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文献和实验Identification of Adipokine Receptor Agonists and Turning Them to Antagonists
organ that secretes a number of biologically active adipokines, including leptin and adiponectin. A recent discovery and design process for leptin and adiponectin receptor response modifier peptides can be generalized to a series
Measurement of Diacylglycerol: Origins of Receptor- Stimulated Diacylglycerol Accumulation
Diacylglycerol (DAG) found within cells is derived from two broad sources. First, in the de novo biosynthetic pathway, glycerol 3-phosphate is converted by two acylation steps to phosphatidic acid (PA), which is converted to DAG by phosphatidate
In Vitro Opioid Receptor Assays
) with selectivity similarly determined by the relative potency at individual opioid receptor subtypes. Partial agonist activity is denoted by PA. Nociceptin is an opioid peptide whose action is not blocked by naloxone
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