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文献和实验-α and IL-1 may constitutively stimulate the signaling pathways leading to NF-κB activation. Activation of the IKK complex either directly by HIV-1 regulatory proteins or by cytokine release leads to the phosphorylation and degradation
TRAF‐Mediated TNFR‐Family Signaling
., Suzuki, N., Xia, Y., and Karin, M. 1999. Signaling by proinflammatory cytokines: Oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino‐terminal effector domain. Genes Dev. 13:1297‐1308
Overexpression Models: Lentiviral Modeling of Brain Cancer
fibroblasts) Ikk2−/− were infected with mock virus (lane 1), H‐RasV12‐shp53 (1 and 2 indicate different clones) plus Cre‐expressing lentivirus (LVs) (lanes 2 and 3), and without (w/o) Cre LV (lane 4). Cell lysates were processed for western blot using anti
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