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文献和实验The Chimeric Human/Mouse Model of Angiogenesis
Angiogenesis, the formation of new blood vessels from preexisting vessels, is an essential component of many normal biological processes such as embryonic development, wound healing, and endometrial maturation in premenopausal women (1 –
Expression of Chimeric Immunoglobulin Genes in Mammalian Cells
recombinant antibodies containing mouse variable domains and human constant domains are characterized by essentially the same antigen-binding properties as the mouse antibodies from hybridomas. The immunogenicity of the chimeric antibodies is lower owing
Transplantation of Chimeric Fetal Liver to Study Hematopoiesis
in various organs, both within the chimera, but also by using functional transplantation assays for hematopoietic stem and progenitor cells. This chapter describes principles and methods for the generation of mouse chimeras, for identification
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