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文献和实验Detection of K-ras Mutations by a Microelectronic DNA Chip
. These potential molecular tumor markers are essential not only for the diagnosis, prognosis, or the follow-up of the disease but also for the management of therapy (1 ,2 ). Particularly, the K-ras protooncogene is altered, by point mutations within codons
A Novel Method for the Production of Fully Modified K-Ras 4B
post-translationally modified proteins in bacterial expression systems is often problematic. Here, we describe a novel recombinant approach to prepare human K-Ras 4B, a protein that is post-translationally farnesylated
Analysis of K-RAS and P53 Mutations in Sputum Samples
Mutations in the P53 tumor suppressor gene and the K-RAS oncogene have frequently been found in sputum and bronchoalveolar lavage (BAL) samples of lung cancer patients, and also in samples from patients prior to presenting clinical symptoms
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