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文献和实验: 1. Prepare Whole Cell Extract. Make sure every solution DOES NOT contain DTT. 2. Add 1 or 2 μl of non-diluted monoclonal antibody (4B4 is better than 10H8 for HSF1) or 1/10 diluted polyclonal antibody to 10 μg of whole cell extract
三句话读懂一篇 CNS,这种治疗可让糖尿病患者脱离胰岛素,感知憋尿感的蛋白竟是它...
-inhibition mechanism of pro-neurodegenerative Sarm1 的研究论文, 该研究阐明了 NAD+ 对于 Sarm1 蛋白功能调控的分子机制。NAD+(Nicotinamide adenine dinucleotide)对于维持轴突的存活至关重要,Sarm1(Sterile alpha and Toll/interleukin-1 receptor motif-containing protein 1)蛋白可以通过降解 NAD+ 促进轴突的退行。 研究人员首先解析
【信息】The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
molecule) are recruited to TIR (Toll/interleukin-1 (IL-1) receptor) domains to initiate signalling, whereas SARM (sterile - and armadillo-motif-containing protein) inhibits TRIF-dependent signalling. MyD88 is the universal adaptor used by all TLRs
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