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文献和实验Modeling Schizophrenia in Neuregulin 1 and ErbB4 Mutant Mice
. However, genetic studies have recently identified many susceptibility genes of this disorder including neuregulin 1 (NRG1 ) and its receptor ErbB4 . Arguably, relevant mutant mice have provided a unique opportunity to model “schizophrenia” in animals
: 1. Prepare Whole Cell Extract. Make sure every solution DOES NOT contain DTT. 2. Add 1 or 2 μl of non-diluted monoclonal antibody (4B4 is better than 10H8 for HSF1) or 1/10 diluted polyclonal antibody to 10 μg of whole cell extract
神经调节蛋白基因之后,会重新获得保护层(protective layer)。 (Fig: Schematic Summary of Abnormalities in Nerves with Altered NRG1 Type III Levels) 参看英文原文: Neuregulin-1 Type III Determines the Ensheathment Fate of Axons Volume 47, Issue
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