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文献和实验The emergence of severe acute respiratory syndrome (SARS) and its subsequent worldwide spread challenged the global public health community to confront a novel infectious disease. The infection is caused by a coronavirus of animal origin
亦称日冕病毒。是从人体上呼吸道组织的器官培养和组织培养所分离出的病毒(D. A. J. Tyrrell, M. C. Bynoe, 1965),是根据其形状因与太阳日冕相似而命名。与流感病毒一样可引起人的感冒症状。病毒粒子为直径 80— 160毫微米的球形,在包膜内侧含有壳包核酸。核酸为单链 RNA。它和流感的正粘病毒( Orthomyxo virus)有近缘关系,但在以下各点则不相同。即:( 1)病毒体( virion)具有球根状突起;( 2)发芽部位为液胞或小胞体;( 3)无神
Purification and Electron Cryomicroscopy of Coronavirus Particles
Intact, enveloped coronavirus particles vary widely in size and contour, and are thus refractory to study by traditional structural means such as X-ray crystallography. Electron microscopy (EM) overcomes some problems associated with particle
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