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文献和实验17 Direct Sequencing for Peutz-Jeghers Gene LKB1 (STK11) Mutations
While Peutz-Jeghers syndrome (PJS) has been acknowledged as a clinical entity for decades (1 ,2 ), the molecular background for the disease has been unraveled only very recently. PJS has two cardinal features: First, many but not all patients
三句话读懂一篇 CNS:喝酒为何拉近社交距离;教科书级成果,RNA 糖基化修饰...
Cancer 杂志发表论文 ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer。研究揭示了 LKB1 缺失所导致的免疫逃逸机制,通过靶向抑制 ATG1 / ULK1 途径,进而抑制细胞自噬,达到抗肿瘤免疫的效应,为治疗 LKB1 突变型非小细胞肺癌(NSCLC)提供新思路! 图 6:站酷海洛 plus7. Cell
: 1. Prepare Whole Cell Extract. Make sure every solution DOES NOT contain DTT. 2. Add 1 or 2 μl of non-diluted monoclonal antibody (4B4 is better than 10H8 for HSF1) or 1/10 diluted polyclonal antibody to 10 μg of whole cell extract
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