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文献和实验Anti-c-erb-B-2 Ribozyme for Breast Cancer
Our laboratory has investigated the cleavage activity of an-anti-c-erb -B-2 ribozyme. The c-erb -B-2 proto-oncogene (also called HER-2/neu ) encodes a 185 kDa transmembrane tyrosine kinase-type receptor that is homologous with the epidermal
Developing Anti-HER2/neu Single-Chain Fv Fragments from Phage Display Libraries
kDa IgG molecule is limited to 1 mm in 2-3 d (4 ). In contrast, smaller molecules such as 50 kDa Fab fragments exhibit faster movement through the tumor interstitium, on the order of 1 to 2 mm per day.
in mitochondria. O2 •– generation by ETC also induces oxidative damage with protein radical formation. Immunospin-trapping with anti-DMPO antibody and subsequent mass spectrometry are used to define the specific site of oxidative damage, indicating cysteine-206
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