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文献和实验The Analysis of Innate Immune Response to Adenovirus Using Antibody Arrays
Even though natural infections with adenovirus (Ad) are largely harmless in humans, an intravenous Ad vector administration for gene delivery purposes, especially at high doses, stimulates strong innate and adaptive immune responses
PEGylated Adenovirus for Targeted Gene Therapy
Bifunctional polyethylene glycol (PEG) molecules provide a novel approach to retargeting viral vectors without the need to genetically modify the vector. Modification of the surface of adenovirus with heterofunctional PEG allows
Transfection Complexes Generated with Adenovirus and Polyethylenimine-Condensed DNA
of high tonic strengths. A coupling technique using antibody-polylysine binding to an adenovirus epitope has been described that allows a greater degree of flexibility in virus-polylysine ratios (17, but requires both an epitope-tagged virus and a special
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