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文献和实验APP-Based Transgenic Models: The APP23 Model
transgenic mouse. This paper describes the development and assessment of this human amyloid precursor protein overexpression model. We summarize histopathological and biochemical, cognitive and behavioral observations made in heterozygous APP23 mice
Rationale The use of mouse genetic models requires an efficient system of unique animal identifiers. The means that tissue must be obtained from each animal for genotyping and that each animal must be tagged so it can be quickly distinguished
An Overview of Transgenic Mouse Production
) and the production of chimeri mice are described in Chapters 23 and 24 .
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