Anti-ACVR2B hIgG1 Antibody(Bim

ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. ACVR2B binds to activin and growth differentiation factor (GDF), which in turn activates type I receptors ansd activates downstream molecules. In addition, mutations in this gene may affect protein function in left and right axis formation and cardiovascular development, as well as reduce muscle mass and bone mass.