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TROP2 is a
carcinoma-associated antigen defined by the monoclonal antibody GA733. This
antigen is a member of a family including at least two type I membrane
proteins. It transduces an intracellular calcium signal and acts as a cell
surface receptor. Mutations of this gene result in gelatinous drop-like
corneal dystrophy, an autosomal recessive disorder characterized by severe
corneal amyloidosis leading to blindness.
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Anti-Trop2 hIgG1 Reference Antibody (Sacbio)
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