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- 详细信息
- 文献和实验
- 技术资料
- 英文名:
Saccharin-13C6
- 库存:
1
- 供应商:
甄准生物
- 保存条件:
Refrigerator
- 规格:
1mg / 10mg
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文献和实验Saccharin Preference in Rats: Relation to Impulsivity and Drug Abuse
In recent years, rats selectively bred for high (HiS) or low (LoS) saccharin intake have provided valuable information regarding vulnerability to drug and food dependence, related affective disorders, and impulsive behavior. The HiS and LoS
Production of Isomaltulose Using Immobilized Bacterial Cells
. They must also have organoleptic and textural properties that make them acceptable to the consumer. Sucrose is an extremely valuable food ingredient: its best-known property is its sweetness but, compared with the “high intensity” sweeteners such as Aspartame� and saccharin
Nat Metab:李贵登等团队合作发现肿瘤内酸度维持 T 细胞干性影响肿瘤免疫治疗
录组学、代谢组学以及同位素(13C6-葡萄糖,13C16-棕榈酸)示踪技术发现,长期胞外酸处理能够抑制 mTOR 信号通路及糖酵解途径,促进 T 细胞内的脂肪酸氧化(FAO),增强线粒体适应性, 从而维持「干性样」T 细胞的代谢表征。进一步深入分析以及通过 13C5-甲硫氨酸代谢流实验,作者们发现胞外酸度的升高显著抑制了 T 细胞内的甲硫氨酸摄入及一碳代谢(甲硫氨酸循环)。 机制上,一方面,胞外酸处理通过抑制 MYC 的表达,降低 T 细胞表面甲硫氨酸转运体(SLC7A5)的表达,进而削弱 T 细胞对胞外
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