(2E,4E,6E)-2,7-二甲基辛-2,4,6-三烯二醛

Nature 子刊：中国团队在扇贝足丝蛋白仿生材料研究领域取得重要研究进展

重组蛋白纤维的力学性质和组装机制研究表明： 1. 重组丝具有扇贝足丝的层级结构和力学性能，具有显著的延展性和自恢复能力（图 2a-d）； 2. 机制研究发现氢键、金属羧基配位和二硫键为主的分子间交联对 rTRM7 纤维的延伸性和自恢复能力有调控作用：纤维内部水分子起到增塑作用从而提高纤维的延伸性，二硫键的存在可以显著增强其拉伸强度同时降低其延伸性，Ca2+与蛋白的羧基形成配位键，并且提高了蛋白分中 β-sheet 含量，从而提高重组蛋白纤维的拉伸强度（图 2e-j）。 图 2. 重组

Spectrophotometric Analysis of Human CYP2E1-Catalyzed p-Nitrophenol Hydroxylation

(5 ) and this is consistent with the finding that hepatic CYP2El protein (6 ) and mRNA (7 ) amounts are increased in alcoholics. Although only a few drugs (e.g., acetaminophen [8 ]) have been identified as substrates for CYP2E1, many low molecular weight procarcinogens

Synthesis of Dipeptides with [CH20] Amide Bond Mimetics

bonds is central to the conversion of peptide leads into pharmaceutically viable molecules. Our strategy utilizes template 1 , which provides derivatives 6b–6e upon alkylation with I, Cl-alkanes (C 3 –C 6 ). Subsequent Finklestein conversion to iodides