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- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
Purified anti-EGFR Phospho (Tyr1068)
- 抗体英文名:
Purified anti-EGFR Phospho (Tyr1068)
- 应用范围:
免疫荧光,流式
- 宿主:
兔
- 供应商:
上海善然生物
- 库存:
4-5周
- 抗原来源:
兔
- 保质期:
2-3年左右
- 适应物种:
人
- 标记物:
Purified
- 克隆性:
单克隆
- 形态:
液体
- 规格:
50ug
Purified anti-EGFR Phospho (Tyr1045) Antibody
Poly23A05
Catalog# / Size 637151 / 50 µL
637152 / 200 µL
Clone
Regulatory Status RUO
Other Names Epidermal Growth Factor Receptor, Receptor Tyrosine-Protein Kinase ErbB-1, Erb-B2 Receptor
Tyrosine Kinase 1, ERBB1, NISBD2, PIG61, MENA
Isotype Rabbit Polyclonal IgG
Description Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that links extracellular
mitogenic ligand binding to complex downstream signaling cascades. Initial ligand binding
results in receptor oligomerization and autophosphorylation of multiple tyrosine residues within
cytosolic domains of the protein. Phosphorylation at tyrosine 1045 allows for binding directly to
the adaptor protein GRB2. EGFR stimulation leads to activation of RAS-RAF-MEK-ERK, PI3
kinase-AKT, PLCγ-PKC and STAT signaling cascades, and constitutive activation of the
receptor promotes tumorigenesis in multiple cancers.
Product Details
Verified Reactivity Human
Antibody Type Polyclonal
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the mature form of human EGFR phosphorylated at tyrosine
1045
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation The antibody was purified by affinity chromatography.
Concentration Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our
Certificate of Analysis online tool.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C.
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