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- 详细信息
- 文献和实验
- 技术资料
- 提供商:
子时(广州)纳米科技有限公司
- 服务名称:
外泌体定制服务项目
- 规格:
10mg/L
· 中文名称
负载小檗碱的外泌体
· 英文名称
berberine@Exosomes
· 表征
DLS、Zeta、TEM、SEM、XRD、FTIR、IR、UV、NIR、XRF、Raman、ICP、载药率、包封率、稳定性、药物释放、细胞安全性、细胞摄取、细胞迁移实验、细胞凋亡、体内分布与代谢、药效评估、安全性评估等等
· 表面修饰及负载
靶向配体、抗体、核酸和环境响应基团修饰、荧光修饰、药物、基因、质粒和蛋白等包封、光敏剂Ce6、磁性Fe3o4等纳米颗粒包封
· 简介
负载小檗碱的外泌体是一种结合天然生物碱与仿生纳米载体的创新递药系统。小檗碱是一种具有抗菌、抗炎、降血糖及抗肿瘤活性的天然生物碱,但其应用受限于溶解性差和吸收率低。将其封装于来源于干细胞或免疫细胞的外泌体中,不仅可通过外泌体的膜结构保护药物免受降解,还能利用其天然的细胞间通讯能力和靶向递送特性,将小檗碱精准运输至病变组织或肿瘤微环境。该系统可显著增强小檗碱的治疗效果,减少非靶向毒副作用,在感染性疾病、炎症性疾病和癌症等领域展现出广阔的应用前景。
负载雷帕霉素的外泌体 RAP@Exosome
间充质干细胞外泌体包裹阿米卡星 MSC-exosomes@AM
负载木犀草素的外泌体 luteolin@Exosomes
三聚磷酸盐修饰负载长春新碱和光敏剂二氢卟吩e6的外泌体 TPP-EXo@VCRCe6
负载青藤碱的外泌体 Sinomenine@Exo
负载维生素A和槲皮素的脂肪间充质干细胞外泌体 VAQue@AMSCs-Exo
透明质酸修饰负载连翘脂苷A的乳源外泌体 HA-mExo@FA
负载五味子乙素和喜树碱的外泌体 EXo@CPTSchisandrin B
负载3-噻吩甲酰胺的外泌体 3-Thiophenecarboxamide@Exosome
负载12-脂氧合酶的外泌体 12-LOX@Exosomes
负载地塞米松的外泌体 DEX@Exosomes
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文献和实验Exosomes are small natural membrane vesicles released by a wide variety of cell types into the extracellular compartment by exocytosis. The biological functions of exosomes are only slowly unveiled, but it is clear that they serve to remove
Exosomes as a Potential Tool for a Specific Delivery of Functional Molecules
Extracellular membrane vesicles derived from the endosomal compartments and released by the fusion of the multivesicular bodies with the cell membrane are referred as exosomes (Exo) [Van Niel et al., J Biochem 140:13–21, 2006]. They function
Isolation of Exosomes for Subsequent mRNA, MicroRNA, and Protein Profiling
Exosomes are nano-sized, cell membrane surrounded structures that are released from many cell types. These exosomes are believed to transport a range of molecules, including mRNAs, miRNAs, and proteins; the contents depending on their cell
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