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- BioLegend
- 145315
- 美国
- 2025年07月12日
- 免疫荧光，流式
- 大鼠
- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
PE/Cyanine7 anti-mouse IL-33Rα (IL1RL1, ST2)
- 抗体英文名：
PE/Cyanine7 anti-mouse IL-33Rα (IL1RL1, ST2)
- 浓度：
0.2 mg/ml
- 应用范围：
免疫荧光，流式
- 宿主：
大鼠
- 供应商：
上海善然生物
- 库存：
现货
- 抗原来源：
大鼠
- 保质期：
2-3年左右
- 适应物种：
小鼠
- 标记物：
PE/Cyanine7
- 克隆性：
单克隆
- 保存条件：
2-8度
- 形态：
液体
- 规格：
25ug
PE/Cyanine7 anti-mouse IL-33Rα (IL1RL1, ST2) Antibody
DIH9
Catalog# / Size 145315 / 25 µg
145316 / 100 µg
Clone
Regulatory Status RUO
Other Names T1/ST2, ST2L, IL-1R1, T1, DER4, IL1R1
Isotype Rat IgG2a, κ
Description IL-33Rα, also known as ST2 or IL-1RL1, is a member of the Toll/IL-1 receptor family. It binds
IL-33 and is structurally similar to IL-1R1. Two forms of the protein exist - a soluble form
known as ST2 and a membrane anchored form known as ST2L. The membrane form is
expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is
expressed by serum-stimulated fibroblasts.
Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and
airway inflammation. The IL-33-ST2 axis has been reported to be important across a range of
diseases including asthma, allergies, and cardiac disease.
Product Details
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen IL-33Rα-hFcγ1 fusion protein.
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under
optimal conditions.
Concentration 0.2 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from
prolonged exposure to light. Do not freeze.
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为啥越老越怕冷？竟是免疫细胞「叛变」了！Cell Metab
人员使用 scRNA-seq 数据检测在衰老小鼠中哪些细胞类型表达 Il33，结果发现其 Il33 基因的表达仅限于一群表达 Msln 的细胞群体中，而不是 Pdgfra+细胞。这些数据表明，在衰老过程中，脂肪组织中 IL-33 的细胞来源发生了转换。qPCR 的检测结果显示，与年轻的小鼠相比，老年小鼠的 VAT 中 Il33 的表达总体增加，但皮下脂肪组织中并没有增加。有趣的是，随着 IL-33 的增加，衰老导致编码 IL-33R 的 Il1rl1 转录变体在老年 VAT 中特异性表达增加，而在血清
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