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- 详细信息
- 技术资料
- 抗体名:
Veligrotug(维古塔单抗)
- 抗体英文名:
Anti-Human IGF1R/CD221 antibody
- 靶点:
IGF1R/CD221,IGF1R, CD221, Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, IGF-I receptor, IGF-1R, IGF-IR
- 适应物种:
human
- 保质期:
12 months
- 目录编号:
CAS:2728655-31-8
- 级别:
Research Grade
- 供应商:
苏州艾洛蒙
- 标记物:
无
- 克隆性:
单克隆
- 保存条件:
Store at -20°C for 12 months (Avoid repeated freezing and thawing)
- 形态:
Liquid
- 亚型:
IgG1 - kappa
- 规格:
1mg/5mg
| 规格: | 1mg | 产品价格: | ¥3000.0 |
|---|---|---|---|
| 规格: | 5mg | 产品价格: | ¥7500.0 |
Veligrotug(维古塔单抗) 是一种 IgG1-kappa、抗 IGF1R (胰岛素样生长因子 1 受体、CD221) 嵌合单克隆抗体。一种针对人胰岛素样生长因子-1受体(IGF-1 R/CD 221)的人源化单克隆抗体,具有潜在的抗胰岛素活性。Veligrotug特异性结合并阻断膜结合的IGF-1 R,阻止天然配体IGF-1的结合和随后的PI 3 K/AKT信号转导的激活,这可能导致诱导细胞凋亡和细胞增殖的减少。IGF-1 R是一种胰岛素受体超家族的受体酪氨酸激酶,被各种癌细胞类型过表达,其激活可刺激细胞增殖,促进血管生成,使致癌转化成为可能,并抑制细胞凋亡。
Veligrotug is an IgG1-kappa, anti-IGF1R (insulin-like growth factor 1 receptor, CD221) chimeric monoclonal antibody.A humanized monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R/CD221) with potential antineoplastic activity. Veligrotug specifically binds to and blocks membrane-bound IGF-1R, preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signal transduction, which may result in the induction of apoptosis and a decrease in cellular proliferation. Activation of IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by various cancer cell types, stimulates cell proliferation, promotes angiogenesis, enables oncogenic transformation, and suppresses apoptosis.
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