IL-2R beta/CD122 His Tag Prote

Interleukin-2 receptor (IL-2R), as the specific receptor of interleukin-2(IL-2), perform their biological functions by binding with IL-2 to transmit signals into cells insides, which induced the downstream signal expression and participated in immune response. The longest IL-2R beta (IL-2Rβ) in the intracellular region has many binding sites for protein phosphorylation. Therefore, IL-2Rβ plays an indispensable role in signal transduction due to its sequence and structural characteristics. IL-2R mediates the multipotency of IL-2 on AC lymphocytes including T cells, B cells and NK cells. The combination of IL-2 and IL-2R complex can cause intracellular signal events and ultimately lead to cell proliferation. In addition, dysregulated expression of the IL-2Rβ abrogates development of NK cells. What’s more important is that T cell proliferation and development of IFNc-producing effector CD8+ T cells depend upon IL-2Rβ.