- ￥1500 - 2079
- 优爱
- 江苏南京
- UA010550
- 2025年11月24日
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50μg/100μg
| 规格： | 50μg | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 100μg | 产品价格： | ￥2079.0 |
Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) is also called PDGF-R-beta and PDGFR, is receptor that binds specifically to PDGFB. PDGFRB is a tyrosine‐kinase receptor for PDGF‐B and PDGF‐D. PDGF-BB secreted by endothelial cells binds to PDGFRB on pericytes, causing the activation of downstream signaling pathways to regulate survival, migration, apoptosis, proliferation, and differentiation. PDGF-BB/PDGFRB signaling is essential for the pericytes-regulated BBB integrity in the stage of development, and adulthood. Furthermore, expression of PDGF-BB/PDGFRB is upregulated in CNS after cerebral ischemia in human and animal models, which is involved in tissue responses especially targeting vascular pericytes. The PDGFRB/EZH2 pathway is critical for promoting cardiomyocyte proliferation and heart regeneration, providing a potential target for cardiac repair.
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文献和实验cells. We present here (i) a detailed protocol for the production and purification of soluble recombinant NK cell receptors tagged with human IgG1-Fc (thus termed receptor-Fc chimera or receptor-Ig fusion protein) and (ii) a protocol for cell staining
【原创】Protein A Sepharose 之进化篇。。。
洗脱条件比较剧烈，最后收集的蛋白质很有可能变性，或者是复性困难。 这种洗脱条件剧烈的Protein A 柱结合的重组蛋白质A一般具有5个串联结构域：E、D、A、B、C。这种重组蛋白A虽然除去了不重要的非结合域，仅由5个结构域组成，每个域均可以和IgG的Fc段结合，但不同的域结合强度略有差异。因此洗脱条件不均一，而且经常需要较低的pH值。如果减少串联结构域的个数，并且采取同型结构域串联，就可以避免不同结构域与抗体Fc 段亲和性的差异，洗脱条件会温和而均一。为此，我们可以做一个试验，比较一下
Capture and Qualitative Analysis of the Activated Fc Receptor Complex from Live Cells
., Saito, N., Larsson, C., Loegering, D., Weber, P.B., and Lennartz, M.R. 2002. A role for PKC‐epsilon in Fc gammaR‐mediated phagocytosis by RAW 264.7 cells. J. Cell Biol. 159:939‐944.
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