Human CD50, His tag

Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a protein that in humans is encoded by the ICAM3 gene. ICAM3 is a 110-160 kDa protein that belongs to the intercellular adhesion molecule (ICAM) family. ICAM3 is a type I transmembrane glycoprotein and consists in part of a hydrophobic transmembrane domain and a short domain that extends into the cytoplasm. ICAM3 also contains 5 extracellular immunoglobulin domains. The protein is constitutively expressed on the surface of leukocytes. ICAM3 mediates adhesion between cells by binding to specific integrin receptors. It plays an important role in the immune cell response through its facilitation of interactions between T cells and dendritic cells, which allows for T cell activation. ICAM3 also mediates the clearance of cells undergoing apoptosis by attracting and binding macrophages to apoptotic cells.