- ￥600 - 2100
- 斯达特
- 浙江杭州
- S0B1152
- 2025年09月10日
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- 详细信息
- 技术资料
- 保存条件：
<p>12 months from date of receipt / reconstitution, -20 °C as supplied</p>
- 供应商：
斯达特
- 规格：
25μl/100μl
| 规格： | 25μl | 产品价格： | ￥600.0 |
|---|---|---|---|
| 规格： | 100μl | 产品价格： | ￥2100.0 |
IDH2 (Isocitrate Dehydrogenase 2) is an enzyme that plays a crucial role in cellular metabolism. It is a key enzyme in the citric acid cycle (also known as the Krebs cycle or TCA cycle), catalyzing the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG) while reducing NADP+ to NADPH. This process is essential for cellular energy metabolism. Mutations in the IDH2 are associated with the development and progression of various types of cancer. These mutations confer a new enzymatic activity on IDH2, converting α-KG to 2-hydroxyglutarate (2-HG), an oncometabolite that accumulates and disrupts epigenetic regulation and gene expression, promoting tumorigenesis.
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