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- 详细信息
- 技术资料
- 保存条件:
12 months from date of receipt / reconstitution, -20 °C as supplied
- 供应商:
斯达特
- 规格:
25μl/100μl/500μl
| 规格: | 25μl | 产品价格: | ¥600.0 |
|---|---|---|---|
| 规格: | 100μl | 产品价格: | ¥2100.0 |
| 规格: | 500μl | 产品价格: | ¥5280.0 |
Calponin-1 is a 34 kDa actin-binding protein with regions of sequence homology to cardiac troponin I and T. It is located in the cytoskeleton and contractile apparatus of differentiated smooth muscle cells. There are 3 isoforms of calponin: calponin-1 (h1 or basic), calponin-2 (h2 or neutral), and calponin-3 (h3 or acidic). Calponin-1 is implicated in the regulation of smooth muscle contraction by mediating intracellular signaling responses to some vasoconstrictors by acting as a contractile scaffold protein. This mechanism is based on results in aortic smooth muscle cells stimulated with phenylephrine, which showed calponin-1 connecting protein kinase C and ERK1/2 pathways to promote contractility.
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