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- 详细信息
- 技术资料
- 保存条件:
12 months from date of receipt / reconstitution, -20 °C as supplied
- 供应商:
斯达特
- 规格:
25 μl/100 μl/500μl
| 规格: | 25 μl | 产品价格: | ¥600.0 |
|---|---|---|---|
| 规格: | 100 μl | 产品价格: | ¥2100.0 |
| 规格: | 500μl | 产品价格: | ¥5280.0 |
Inducible T cell costimulatory factor (ICOS, cluster of differentiation, CD278) is an activated costimulatory immune checkpoint expressed on T cells. Its ligand ICOSL was expressed in antigen-presenting cells and somatic cells (including tumor cells in the tumor microenvironment) [PMID: 28713380, PMID: 12800259]. As one of the most common targeted immune checkpoints, ICOS is considered a possible way to develop new immunotherapy [PMID: 29544515]. Some clinical studies shown that blocking ICOS alone can inhibit tumor growth and proliferation, as well as TIGIT, CTLA4, and PD-1 [PMID: 30232519, PMID: 28803728].
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