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- 详细信息
- 技术资料
- 保存条件:
<p>12 months from date of receipt / reconstitution, -20 °C as supplied</p>
- 供应商:
斯达特
- 规格:
25μl/100μl
| 规格: | 25μl | 产品价格: | ¥600.0 |
|---|---|---|---|
| 规格: | 100μl | 产品价格: | ¥2100.0 |
is an HSP90 paralogue that is found in the endoplasmic reticulum. It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins. It has been implicated as an essential immune chaperone to regulate both innate and adaptive immunity. Grp94 has been shown to be a target for treatment of a plethora of diseases such as glaucoma, multiple myeloma, and metastatic cancer. grp94 includes 5 distinct amino acids in its primary sequence which creates 2 unique sub-pockets, S1 and S2. These sub-pockets have been utilized in current research in order to inhibit the chaperone since its client proteins seem to be up-regulated in cancer cells.
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