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huayun / β-NGF/ NGF/ NGFB (Ser

122-Ala241, E.coli), Human, Recombinant，HYPC5086
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  • ￥2340
  • 华韵生物(Huayunbio)
  • HYPC5086
  • 2025年07月11日
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    广州华韵生物科技有限公司
    2 年钻石会员

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    • 供应商：

      广州华韵生物科技有限公司

    • 规格：

      10µg

    产品信息

    别名Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB
    物种Human
    表达宿主E.coli
    序列信息Ser122-Ala241
    检索号P01138
    分子量13.4 kDa
    表观分子量14 kDa
    生物活性 Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.03-0.3 ng/ml.

    产品特性

    纯度 >95% as determined by reducing SDS-PAGE.
    内毒素< 1.0 EU per µg as determined by LAL test.
    保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2~8℃ for 2~7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
    运输 Ambient temperature or ice pack.
    制剂Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    复融Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    背景介绍

    Human β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits α, β, and γ; it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of Growth Factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its Receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic Cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90% sequence similarity with mouse Protein and shows cross-species reactivity.

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    图标文献和实验
    相关实验

    • 　白细胞分化抗原--　白细胞分化抗原的分类

      ,2F12;CRIS-3　 Leu LFA-1(gp180/95)的α链 与ICAM-1（CD54）和ICAM-2（CD102）结合 CD11b Mol,OKM1; (Mac-1,CR3,integrin αm　 G,M,NK gp165/95的α链 C3bi和FB受体，与ICAM-1结合，粘附，调理吞噬 CD11c LeuM5;(CR4,integrin αx) M,G,NK,Tsub gp150/95的α链 C3bi受体，调理吞噬          

    • v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平

      and has high inherent activity but is inhibited by activation of Wnt signalling oractivation of growth factor receptor tyrosine kinases (e.g. insulin, nerve growth factor [NGF], plateletderivedgrowth factor [PDGF], etc.). The degree of inhibition of GSK

    • 　白细胞分化抗原

      4,(integrinβ1,FNRβ) 广泛分布 gp130,GPⅡa 与ECM粘合，细胞间粘附，结合VCAM-1（CD106） CD30 Ki-1　 Ta,Ba,Rs gp105,NGF受体家族 与淋巴细胞存活和增殖有关 CD31 SG

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