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huayun / RANK/ TNFRSF11A/ CD26

5 (C-6His), Human, Recombinant,HYPC5076
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  • ¥3600
  • 华韵生物(Huayunbio)
  • HYPC5076
  • 2025年07月16日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 供应商

      广州华韵生物科技有限公司

    • 规格

      10µg

    产品信息

    别名CD265; ODFR; TNFRSF11A; TRANCE R; CD265; CD265 antigen; FEO; ODFROSTS; OFE; OPTB7; PDB2; RANK1; Receptor activator of NF-KB; Receptor activator of nuclear factor-kappa B; TRANCER; tumor necrosis factor Receptor superfamily member 11A
    物种Human
    表达宿主Human Cells
    序列信息Ile30-Pro212
    检索号Q9Y6Q6
    分子量21.1 kDa
    表观分子量25-30 kDa
    标签C-6His
    生物活性 Loaded Human RANK-His on HIS1K Biosensor, can bind Human RANK L with an affinity constant of <1 pM as determined in BLI assay.

    产品特性

    纯度 >95% as determined by reducing SDS-PAGE.
    内毒素< 1.0 EU per µg as determined by LAL test.
    保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2~8℃ for 2~7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
    运输 Ambient temperature or ice pack.
    制剂Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    复融Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    背景介绍

    Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor Receptor (TNFR) molecular superfamily. RANK is the Receptor for RANK-Ligand (RANKL) and part of the RANK/ RANKL/ OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas.

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