Guinea pig抗II型胶原抗体(Anti-CIIAb)

盘点∣类风湿性关节炎的动物模型有哪些？

物来诱导关节炎的发生。 具体操作：8 周龄的雄性 DBA/1 小鼠，在 0d 时腹膜腔注射鼠单克隆 II 型胶原抗体，3d 后腹膜腔注射大肠杆菌脂多糖（LPS）。初次免疫后 d4 有炎症迹象，d6-d8 关节炎达到最严重，出现足踝和足趾明显红肿、炎症细胞浸润和血管翳形成等症状[9-10]。 模型特点：作为 CIA 模型的扩展，CAIA 模型可用于不适合 CIA 的菌株或基因型，并在短时间内快速发病，发病率、可重复性及稳定性较高，但所需试剂昂贵，造模成本偏高。 表 1. 常用诱导型类风湿性关节炎模型比较

Methods for Evaluation of Antiviral Efficacy Against Influenza Virus Infections in Animal Models

Compounds undergoing preclinical development for anti-influenza virus activity require evaluation in small animal models. Laboratory mice are most commonly used for initial studies because of size, cost, and availability. Cotton rats, guinea

疟原虫 Malaria Parasites(Plasmodium)

is the most commonly seen species. P.malariae is present in Africa, South America and in one area of New Guinea. P. ovale is relatively unusual outside Africa although some cases are now being identified in other regions(eg. Southern States of India).A number of new