Anti-Metabotropic Glutamate Re

Aspects of CNS Lupus: Mouse Models of Anti-NMDA Receptor Antibody Mediated Reactivity

of interest binds the N -methyl-d -aspartate receptor (NMDAR), a receptor for glutamate that is a major excitatory neurotransmitter in the brain involved in synaptic plasticity, in memory and learning, and in emotional responses. We introduce basic

三句话读懂一篇 CNS：橙子可甜可酸的原因；吃红肉促进结直肠癌发生的分子机制...

on the colonic capillaries as a novel pharmacological target for IBD therapy. Sig Transduct Target Ther 6, 235 (2021). https://doi.org/10.1038/s41392-021-00626-z3. Lin, S., Han, S., Cai, X. et al. Structures of Gi-bound metabotropic glutamate receptors mGlu

3 分钟 get 大热的 PD-L1 免疫疗法

-L1 的结合会下调 T 细胞的活性，阻断体内免疫系统对肿瘤细胞的攻击。PD-1/PD-L1 单克隆抗体是目前临床研究与应用最广泛的免疫检查点抑制剂。当阻断 PD-1 与 PD-L1 的结合时，负调控信号被阻断，T 细胞恢复活性，杀死肿瘤细胞，在多种癌症治疗过程中显示出卓越的疗效[5]。图 2：PD-1/PD-L1 抑制剂的工作机理[6]TCR, T cell receptor; MHC, major histocompatibility complex;APC, antigen presenting