- ￥5148
- 华韵生物(Huayunbio)
- HFC3839-100Tests
- 2025年07月12日
- FCM
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- 详细信息
- 文献和实验
- 技术资料
- 保质期：
12个月
- 供应商：
广州华韵生物科技有限公司
- 应用范围：
FCM
- 规格：
100Tests
请联系华韵客服获取说明书。
产品简介：
| Background |
FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.
|
| Alternate Names |
Forkhead box protein P3;Foxp3;IPEX;JM2
|
| Swissprot |
Q99JB6
|
| Gene ID |
50943,20371,317382
|
| Clone No |
3G3
|
| Host |
Mouse
|
| Reactivity |
Mouse
|
| Application |
ICFCM
|
| Isotype |
Mouse IgG1, κ
|
| Isotype Control |
APC Mouse IgG1, κ Isotype Control[MOPC-21]
|
| Conjugation |
APC
|
| Conjugation Information |
APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).
|
| Spectrum |
|
| Storage Buffer |
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
|
| Storage |
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
|
| Expiration date |
12个月
|
| Shipping |
冰袋
|
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文献和实验，表现出Th1、Th2和TFH等具有传统功能的细胞亚群。导致Foxp3下调的关键因素包括高水平的炎症因子内环境，如可诱导效应性T细胞产生的细胞因子：IL-6和IFN-gamma。Tregs 细胞中Foxp3的表达分析CD4+CD25+ Treg 细胞中Foxp3 +细胞群表明与Foxp3+Treg完全重合。使用Foxp3鉴定Treg用Anti-Mouse CD4 FITC、Anti-Mouse CD25 APC和Anti-Mouse/Rat Foxp3 PE 标记BALB/c小鼠 脾细胞. 右上
Intracellular Immunofluorescent Staining for Flow Cytometry
supernatant. [OPTIONAL] Block with 2% (2 µl) normal rat serum in 1X Permeabilization Buffer, in approximately 100 µl volume, at 4°C for 15 minutes. Without washing after blocking step, add 20 µl fluorochrome conjugated anti-human Foxp3 antibody
激不比激素附着于受体的物质，如三苯氧胺。 Anti-oxidant 抗氧化剂，凡能与氧化剂反应或阻止其形成而阻止氧化的化学物质，如维生素C有助于阻止DNA的氧化。 Anti-oxodant nutrient 抗氧化营养素，具有中和破坏性自由基从而抑制氧化性损伤的营养物质，如β胡萝卜素及维生素E或C。 Antisense(therapy) 反义疗法，一种治疗癌症的技术，用一种寡核苷酸结合靶RNA以抑制特异基因的表达
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