- ￥1053
- 华韵生物(Huayunbio)
- HFC3606-50Tests
- 2025年07月06日
- FCM
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- 详细信息
- 文献和实验
- 技术资料
- 保质期：
12个月
- 供应商：
广州华韵生物科技有限公司
- 应用范围：
FCM
- 规格：
50Tests
请联系华韵客服获取说明书。
产品简介：
| Background |
IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.
|
| Alternate Names |
CTLA-8;CTLA8;Cytotoxic T-lymphocyte-associated antigen 8;IL-17;IL-17A;Interleukin-17A
|
| Swissprot |
Q62386
|
| Gene ID |
16171
|
| Clone No |
TC11-18H10.1
|
| Host |
Rat
|
| Reactivity |
Mouse
|
| Application |
ICFCM
|
| Isotype |
Rat IgG1, κ
|
| Isotype Control |
PE Rat IgG1, κ Isotype Control[HRPN]
|
| Conjugation |
PE
|
| Conjugation Information |
PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).
|
| Spectrum |
|
| Storage Buffer |
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
|
| Storage |
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
|
| Expiration date |
12个月
|
| Shipping |
冰袋
|
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文献和实验）固定能有效保留EYFP荧光，但FoxP3染色的强度和阳性细胞比例却明显下降。同样，CD8⁺ T细胞中T-bet的染色也显著减弱。在已知均一表达RORγt的双阳性（DP）胸腺细胞中，PFA固定严重削弱了RORγt信号；然而，在实验性自身免疫性脑脊髓炎（EAE）小鼠中枢神经系统浸润的CD4⁺ T细胞中，IFN-γ和IL-17A的细胞因子染色在各种胞内染色方法下表现相似。为平衡荧光保留与转录因子检测，研究人员降低PFA浓度并调整固定时间，随后使用试剂盒的Perm缓冲液进行破膜。结果显示，延长固定
Assay Cell Enrichment and Detection Kit(PE)Mouse IL-2 Secretion Assay Cell Enrichment and Detection Kit(PE)Mouse IL-4 Secretion Assay Cell Enrichment and Detection Kit(PE) Mouse IL-5 Secretion Assay Cell Enrichment and Detection Kit(PE) Mouse IL-10
Intracellular Immunofluorescent Staining for Flow Cytometry
Right: Mouse splenocytes were stimulated for 3 days with IL-2. Cells were surface stained with APC CD49d (DX5) (Cat. No. 17-5971 ) and subsequently stained intracellularly with PE GB11. Human IL-17 (eBio64CAP17): Human
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