Mouse ER (Estradiol Receptor)

Identification of ImmediateEarly Gene Targets of the Raf-1 Serine/Threonine Protein Kinase Using an Estradiol-Dependent Fusion Protein, Raf-1:ER

, and hormone receptors into the nucleus (1 –4 ). Receptor-dependent activation of the Ras GTPase results in recruitment of Raf-1 to the plasma membrane whereupon Raf-1 kinase is activated by a mechanism that is not yet fully elucidated. Subsequently, Raf

Neurotransmitter Receptor Analysis in Transgenic Mouse Models

One of the characteristic findings in human Huntington’s disease (HD) is the alteration of neurotransmitter receptors. To a remarkable degree, transgenic HD mouse models recapitulate neurotransmitter receptor alterations. Neurotransmitter

Chromatin immunoprecipitation assay detects er recruitment to gene specific promoters in uterus

interested in examining estrogen-dependent transcriptional mechanism in respect of recruitment of estrogen receptor-alpha (ERα), a ligand-activated transcription factor, to uterine gene promoters in mice. Recent genearray studies, utilizing ERα knock-out vs