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文献和实验The Extracellular Signal-Regulated Kinase (ERK) Cascade in Neuronal Cell Signaling
The Ras-controlled extracellular signal-regulated kinase (ERK) pathway mediates a large number of cellular events, from proliferation to survival, from synaptic plasticity to memory formation. In order to study the role
Recently, it has been shown that enzymes of the cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE) family 4 can be directly phosphorylated by extracellular signal-regulated kinase 2 (ERK2). Phosphorylation of PDE4s by ERK2
Reconstitution of the Nuclear Transport of the MAP Kinase ERK2
The nuclear–cytoplasmic distribution of ERK2 is regulated in response to various stimuli and changes in cell context. Furthermore, the nuclear flux of ERK2 occurs by several energy- and carrier-dependent and -independent mechanisms. ERK2
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