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文献和实验Adenoviral Gene Expression and Replication in Human Tumor Explant Models
Promising results have been reported from numerous studies with replication-selective oncolytic adenoviral mutants as novel treatments for a variety of cancers. Most of these studies were performed in cancer cell lines, dissociated tumor
Replication Initiation Point Mapping: Approach and Implications
is a sensitive technique and has been successfully applied to single copy loci in both budding and fission yeast, archaebacteria, and human cells. Studies in yeast have shown that the binding site for the initiator, the origin recognition complex (ORC), lies
In Vivo Imaging of Human Cancer with Telomerase-Specific Replication-Selective Adenovirus
replication (TelomeScan, OBP-401). We used TelomeScan to establish a new approach for visualizing metastatic or disseminated human tumors in vivo. Visualization is achieved via illumination with an �excitation lamp under a three-chip color-cooled charged
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