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文献和实验MUC1 Expression in Lung Cancer
Abnormalities in mucin-type glycoprotein expression have been documented in a variety of cancers, identifying these molecules as targets for immunologically based therapies and prognostic/diagnostic assays. Epithelial mucin proteins
the features of MUC1 that regulate the membrane trafficking of this mucin-like transmembrane protein. Previous studies using heterologous expression of MUC1 in CHO and MDCK cells revealed that trafficking to the cell surface as well as endocytosis and recycling
with pancreatic cancer (1,2), and these mucins may express a wide range of different carbohydrate structures The detection and quantification of mucin can be used in serological diagnosis of the disease.
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