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文献和实验, and hormone receptors into the nucleus (1 –4 ). Receptor-dependent activation of the Ras GTPase results in recruitment of Raf-1 to the plasma membrane whereupon Raf-1 kinase is activated by a mechanism that is not yet fully elucidated. Subsequently, Raf
Chromatin immunoprecipitation assay detects er recruitment to gene specific promoters in uterus
interested in examining estrogen-dependent transcriptional mechanism in respect of recruitment of estrogen receptor-alpha (ERα), a ligand-activated transcription factor, to uterine gene promoters in mice. Recent genearray studies, utilizing ERα knock-out vs
). It has been demonstrated that fgf and shh expression levels are corelated in a manner indicative of a regulatory relationship in the in developmental systems includig the limb (Gilbert 2000). To study the effect of fgf signaling on early chicken development, we interfered
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