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文献和实验The Rat Aortic Ring Assay for In Vitro Study of Angiogenesis
Angiogenesis is necessary for growth and metastasis of cancer. It is comprised of several distinct steps, including degradation of extracellular matrix, cell migration, proliferation, and structural reorganization (1 ). Inhibition
Rat Aortic Ring: 3D Model of Angiogenesis In Vitro
Angiogenesis is a necessary component of normal tissue repair, tumor growth and dissemination, and a wide variety of other inflammatory and pathological processes as well, including diabetic retinopathy, rheumatoid arthritis, and psoriasis
Three-dimensional In vitro Angiogenesis in the Rat Aortic Ring Model
, migration, or tube formation. The two-dimensional nature of the assays also ignores the differences in endothelial phenotype seen in three-dimensional models and in vivo . The in vitro serum-free three-dimensional rat aortic model closely approximates
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