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文献和实验Human Antibodies by Guided Selection
Guided selection is a method for humanization of pre-existing non-human (for example, mouse) antibodies, based on chain shuffling of V-genes by using phage display technology. Mouse VH and VL domains are used to guide the selection of a human
Therapeutic Human Monoclonal Antibodies in Inflammatory Diseases
almost any cell surface or secreted molecule with remarkable efficacy and safety. In this chapter, the application of human mAbs in the treatment of inflammatory diseases is reviewed. We discuss in detail several mAb-based drugs such as anti-tumor necrosis factor
Production of Human Antibodies from Transgenic Mice
Mice transgenic for human immunoglobulin genes offer the opportunity to investigators to derive fully human antibodies using well-established hybridoma technology. Several different strains of such mice are available, and can be obtained
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