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文献和实验Molecular Analysis of Human Resistance to Thyroid Hormone Syndrome
Resistance to thyroid hormone (RTH) syndrome is an inherited human endocrine disease, which is manifested as a failure to respond properly to elevated circulating thyroid hormone (1 -4 ). RTH syndrome behaves as an autosomal dominant trait
The Role of Thyroid Hormone Receptors in the Heart
out to investigate the effects of a mutant thyroid hormone receptor β1 expressed in the heart. The mutated cDNA was originally cloned from a human patient by Usala et al. (1 ) and had been sequenced to reveal a 3 bp deletion at positions 1295-1297, which led
Introduction to Thyroid Hormone Receptors
, and heart rate in vertebrates (Fig. 1 ). Aberrant functions of TRs induce tremendous defects in these pathways. For example, the human disease of Resistance to Thyroid Hormone (RTH) ( see Chapter 8 by Yoh and Privalsky) is a genetically autosomal
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