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文献和实验The discovery of two isoforms of the cyclooxygenase (COX) enzyme, COX-1 and COX-2, has provided the rationale for development of selective COX-2 inhibitors as a class of safer drugs for the treatment of pain, symptoms of osteoarthritis
Quantitative Analysis of Cyclooxygenase Metabolites of Arachidonic Acid
, catalyzed insertion of oxygen occurs enzymatically via action of one of the two known cyclooxygenase isoenzymes (COX-1 and COX-2). The unstable bicyclic intermediate, PGH 2 , undergoes subsequent metabolism to form prostaglandins (PG), thromboxane
Localization and Distribution of Cyclooxygenase-2 in Brain Tissue by Immunohistochemistry
was first cloned from sheep seminal vesicles in 1988 (1 ,2 ). In 1991, we and others reported the cloning of a second isoform of cyclooxygenase, now known as COX-2, that is rapidly induced in response to growth factors and proinflammatory cytokines
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