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文献和实验Molecular and Functional Characterization of P-Glycoprotein In Vitro
in and out of the central nervous system. Several membrane-associated transport proteins, such as P-glycoprotein (P-gp), multidrug resistance-associated proteins, breast cancer resistance protein, and organic anion transporting polypeptides, have been characterized
Screening for P-Glycoprotein (Pgp) Substrates and Inhibitors
P-glycoprotein (P-gp), the product of the human ABCB1 gene and often called MDR1, is the best understood membrane protein known to be involved in the active transport of drugs across biological membranes. In addition to mediating or limiting
An Enzymatic Microplate Assay for Testing P-Glycoprotein Substrates and Inhibitors
P-Glycoprotein (P-gp) is a multidrug transporter responsible for resistance to anticancer chemotherapy and physiologically involved in absorption, distribution, and excretion of a large number of hydrophobic xenobiotics. P-gp exhibits
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