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文献和实验The unilateral 6-hydroxydopamine mouse model has received considerable attention of late as a model complementary to the hemi-parkinsonian rat. Although both species are similar in nature, there are significant differences
6-OHDA Lesion Models of Parkinsons Disease in the Rat
The 6-hydroxydopamine (6-OHDA) lesion of the rat nigrostriatal pathway is the most widely used animal model of Parkinson’s disease. 6-OHDA is a highly specific neurotoxin which targets catecholamine neurones via the dopamine active
ADHD Animal Model Characterization: Transcriptomics and Proteomics Analyses
treatment with 6-hydroxydopamine (6-OHDA) and congenic wiggling (Wig) rats show motor hyperactivities during a period of darkness at 4 weeks of age. In rats with 6-OHDA lesions, subcutaneous injection of methamphetamine attenuates hyperactivity, the reverse
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