兔 IGFBP-5 (Insulin Like Growth

Alterations in the Expression of Insulin-Like Growth Factors and Their Binding Proteins in Lung Cancer

The insulin-like growth factors (IGF), named for their structural homology to proinsulin, are potent mitogens involved in the endocrine, paracrine, and autocrine regulation of growth. IGF bioactivity may be altered by changes to any level

Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk

Insulin-like growth factors (IGFs) are mitogenic peptide hormones involved in the regulation of cell proliferation, differentiation, transformation, and apoptosis. The members of the IGF family include two types of peptides (IGF-1 and IGF

神经生长因子 nerve growth factor

的蛋白质，由两个亚单位构成的二合体或多合体显有活性。另一方面，瓦恩（S.Varon，1967）认为，活性成分是分子量约为14万的蛋白质，具有分子量约为3万的α、β、γ三种亚单位，仅β表现有NGF活性。将精制的NGF注射于鸡胚或初生小鼠，则发育中的感觉和交感神经节细胞的有丝分裂频率增高，细胞数增加，神经节体积显著增大。将兔的NGF抗血清注射于怀孕小鼠或初生小鼠等哺乳类，则生出来的幼体及实验个体的交感神经细胞出现选择性的坏死（免疫去交感）。对于培养中的神经节，其促进纤维生长和再生效果也是显著