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文献和实验与配体的结合,发挥细胞粘附功能。 图2-6 Cadherin分子的结构模式图 注:图中黑区部分显示Cadherin分子内重复结构域;LDRE及DXNDN为重复序列。 (二)Cadherin家族的组成和分布 目前已知Cadherin家族共有3个成员:E-Cadherin、N-Cadherin和P-Cadherin。E-Cadherin也被称作Uvomorulin、L-CAM或Cell-CAM120/80。不同
Cadherin-Mediated Cell-Cell Interactions
P-Cadherin Human, mouse, bovine Placenta (mouse), skin, breast (myoepithelial cells), prostate (basal cells) R-Cadherin (cadherin
Tracking the Transport of E-Cadherin to and From the Plasma Membrane
, it is also a key occurrence in many diseases, including cancers of epithelial origin E-cadherin is a central component of adherens junctions (AJs), which act as structural and signaling hubs in epithelial cells that oppose EMT. The loss of E-cadherin
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