小鼠 TRH (Thyrotropin-releasing

促甲状腺激素释放激素（thyrotropin-releasing hormone，TRH）

　　 为下丘脑中促垂体激素的一种。其成分为肽类。等克分子量的谷氨酸，组氨酸及脯氨酸结合成三肽，即：焦性谷氨酸—组氨酸—脯氨酰胺。分子量为362。TRH广泛分布于下丘脑以外的脑脊髓部分。为内源性中枢刺激物。如低等脊椎动物无垂体但体内TRH含量多，表明其原始作用为调节神经系统功能。可能作为递质存在。由下丘脑分泌的TRH经垂体门脉运至腺垂体，作用于腺垂体的促甲状腺细胞，与细胞膜上受体结合，激活腺苷酸环化酶-cAMP-蛋白激酶系统，使促甲状腺细胞合成与释放促甲状腺激素，并维持其正常分泌

Null Mutant Mice for Thyroid Hormone Receptors

of two peptidic hormones, thyrotropin-releasing hormone (TRH) in the hypothalamus and thyroid-stimulating hormone (TSH) in the pituitary. TRH normally stimulates the production of TSH, which, in turn, stimulates the thyroid gland and thus permits an efficient TH

Prodrug Design for Brain Delivery of Small- and Medium-Sized Neuropeptides

for brain delivery of small neuropeptides, pGlu-Glu-Pro-NH2 , [Glu2 TRH], a thyrotropin-releasing hormone (TRH) analogue with a vast array of central activities, was chosen as an example. An ester prodrug provided significantly improved brain