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文献和实验Molecular Biological Identification and Characterization of Inherited Platelet Receptor Disorders
coagulation. These factors include factor VIII, vWF, factor V, Multimerin, fibrinogen, factor XIII, factor XI, thrombospondin, fibronectin, �-thromboglobulin (�TG) and platelet factor 4 (PF4). Some of these factors are actively synthesized in megakaryocytes
Heparin-Induced Thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating immunoglobulin (Ig) G antibodies that recognize multimolecular complexes of platelet factor 4 (PF4) bound to heparin or other polyanions. Most laboratory assays for HIT
Molecular Biology Studies with Primary Megakaryocytes
such as the integrin αIIb and platelet factor 4 (PF4). Other proteins such as the platelet-restricted G protein Gz α has not been detected in any of these cell lines. Further, these cell lines often express a mixture of multiple different lineages and can be easily
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