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文献和实验The insulin-like growth factors (IGF), named for their structural homology to proinsulin, are potent mitogens involved in the endocrine, paracrine, and autocrine regulation of growth. IGF bioactivity may be altered by changes to any level
Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk
Insulin-like growth factors (IGFs) are mitogenic peptide hormones involved in the regulation of cell proliferation, differentiation, transformation, and apoptosis. The members of the IGF family include two types of peptides (IGF-1 and IGF
和GHIH调控。GH的分泌呈脉冲式,并存在明显的昼夜节律,脉冲式分泌期外几无释放。主要在夜间熟睡后约1 h起(睡眠脑电图时相3、4期),有数次较大的脉冲式分泌。 (二)生长激素依赖性胰岛素样生长因子 生长激素依赖性胰岛素样生长因子(GH-dependent insulin-like growth factor, IGF)即生长调节素(somatomedin, SM)。IGF为一族化学结构与胰岛素相近,有促进生长作用和一定胰岛素样作用的细胞因子。GH的促生长
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