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文献和实验Interleukin 15 (IL-15) has been described as a cytokine with biologic functions similar to those of IL-2. IL-2 and IL-15 utilize a receptor composed of three subunits: IL-2 receptor β-chain, the y-chain (βc) shared by IL-15, IL-2, IL-4, IL
receptor consisting of an α-, β-, and γ-chain. The γ- chain is shared with a number of other cytokines such as IL-3 and IL-7, which also play a role in cell growth (2 ). The IL-2 receptor β- chain also comprises part of the receptor for IL-15.
Overview of Receptor Allosterism
. Bruns, R.F. and Fergus, J.H. 1990. Allosteric enhancement of adenosine A1 receptor binding and function by 2‐amino‐3‐benzoylthiophenes. Mol. Pharmacol. 38:939‐949.
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