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文献和实验Molecular Analysis of Complement Component C4 Gene Copy Number
isotypes (C4A and C4B) may also lead to susceptibility to autoimmune disease. Therefore, in subjects with autoimmune disease, a low serum C4 level may be due to ongoing disease activity associated with complement activation and consumption
Human Complement Components C4A and C4B Genetic Diversities: Complex Genotypes and Phenotypes
. 2000. Deficiencies of human complement component C4A and C4B and heterozygosity in length variants of RP‐C4‐CYP21‐TNX (RCCX) modules in Caucasians: The load of RCCX genetic diversity on MHC‐associated disease. J. Exp. Med. 191:2183‐2196
Allotyping of Complement Components
, some with several tens of different allotypes. The study of the major histocompatibility complex (MHC)-encoded complement components C4A and C4B was particularly rewarding because of their association with human lymphocyte antigens (HLA) and because of their presence
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